Geir Isaksen

Postdoctoral Fellow
Image of Geir Isaksen
Phone +47 776 23178
Room C-325
Postal address CTCC Department of Chemistry N-9037 Tromsø Norway University of Tromsø

Research interests

Enzyme cold adaptation

  • Emperical Valence Bond theory (EVB)
  • Reaction dynamics
  • Thermodynamic activation parameters
  • Enzyme mobility
  • Electrostatics

Enzyme design

  • Tuning of thermodynamic activation parameters
  • Mutational modeling
  • Optimization of reaction rates
  • Lowering of enzyme temperature optimum

Drug design

  • Small cationic antimicrobial peptides
  • Proteolytic stability towards tryptic and chymotryptic degradation
  • Molecular modeling of binding modes
  • Pharmacophore development and chemometrics
  • Isothermal titration calorimetry

Cell membrane modeling

  • Molecular dynamic simulation of drug molecule interactions with bacterial cell membranes
  • Linear interaction energy


  • Masters degree in Chemistry, University of Tromsø, 2010.
  • "Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation"

Selected publications

1. Karstad, R., Isaksen, G., Brandsdal, B. O., Svendsen, J. S., and Svenson, J. (2010) Unnatural amino acid side chains as S1, S1', and S2' probes yield cationic antimicrobial peptides with stability toward chymotryptic degradation, Journal of medicinal chemistry 53, 5558-5566.

2. Flaten, G. E., Kottra, G., Stensen, W., Isaksen, G., Karstad, R., Svendsen, J. S., Daniel, H., and Svenson, J. (2011) In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides, Journal of medicinal chemistry 54, 2422-2432.

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Published Mar. 5, 2012 8:27 AM - Last modified Feb. 2, 2016 8:17 AM